An individual who has eaten far too much diazepam typically shows a number of of those indicators inside a duration of roughly 4 hours right away subsequent a suspected overdose:[38][89]
Remedies are usually not suggested, given that side effects will normally outweigh the benefits.
enasidenib will boost the level or outcome of diazepam by influencing hepatic enzyme CYP2C19 metabolism. Use Caution/Watch. Enasidenib (a weak CYP2C19 inhibitor) may well improve systemic publicity of delicate CYP2C19 substrates. Check and regulate dose of substrate as clinically indicated.
fentanyl iontophoretic transdermal technique and scopolamine both of those improve sedation. Prevent or Use Alternate Drug. Limit use to people for whom substitute cure selections are insufficient
Reserve concomitant prescribing of these drugs in people for whom other cure alternatives are inadequate. Limit dosages and durations into the bare minimum demanded. Keep track of closely for indications of respiratory melancholy and sedation.
deferasirox will lessen the extent or outcome of diazepam by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep an eye on.
If this isn't possible, give drug into tubing of the flowing IV Answer as shut as you possibly can to vein insertion
diazepam decreases levels of acetaminophen rectal by increasing metabolism. Small/Importance Unknown. Increased metabolism incr levels of hepatotoxic metabolites.
cyclosporine will raise the level or result of diazepam by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Watch.
If symptom relief not obtained right after 3rd administration, adjunctive therapy suitable for the situation is recommended Discontinuation or dosage reduction
aprepitant will boost the degree or impact of diazepam by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep track of.
Reserve concomitant prescribing of view those drugs in people for whom other therapy selections are insufficient. Limit dosages and durations on the least demanded. Keep track of closely for indications of respiratory melancholy and sedation.
Place affected individual on aspect facing you with upper leg bent forward, lubricate rectal applicator tip, gently insert syringe idea in rectum and bit by bit press plunger
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